Leucovorin Sodium

Preferred Label : Leucovorin Sodium;

NCIt synonyms : Sodium Folinic Acid; Sodium Folinate;

NCIt definition : The sodium salt of leucovorin, an active metabolite of folic acid, used as an antidote to folic acid antagonists. Leucovorin does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonists and counteracts the toxic effects of these drugs. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity. In comparison with the calcium salt, sodium salt does not form precipitate when mixed other folate antagonists.;

UNII : 4MXU9LJS4Q;

InChIKey : FSDMNNPYPVJNAT-RIWFDJIXSA-L;

CAS number : 163254-40-8;

Chemical formula : C20H21N7O7.2Na;

Details

Origin ID

C97555;

UMLS CUI

C3273487;

Automatic exact mappings (from CISMeF team)
- sodium folinate [ATC Code]
Currated CISMeF NLP mapping
- Disodium folinate [SMS substance]
- Sodium folinate [ICD-11 Extension code]
- Sodium folinate (substance) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Sodium folinate (substance) [SNOMED CT concept]
- sodium folinate [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_free_acid_or_base_form
- Leucovorin [NCIt concept]
is_salt_form_of
- Leucovorin [NCIt concept]

Keyword's position in hierarchy(ies) :

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