Preferred Label : Famitinib;
NCIt synonyms : 4H-pyrrolo(3,2-c)pyridin-4-one, 5-(2-(diethylamino)ethyl)-2-((5-fluoro-1,2-dihydro-2-oxo-3h-indol-3-ylidene)methyl)-1,5,6,7-tetrahydro-3-methyl-;
NCIt definition : An orally bioavailable receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic
activity. Famitinib binds to and inhibits several RTKs, dysregulated in a variety
of tumors, including stem cell factor receptor (c-Kit; SCFR), vascular endothelial
growth factor receptor (VEGFR) 2 and 3, platelet-derived growth factor receptor (PDGFR)
and FMS-like tyrosine kinases Flt1 and Flt3. Inhibition of these RTKs may result in
an inhibition of tumor growth and angiogenesis, and eventually tumor regression in
tumor cells overexpressing these RTKs.;
UNII : 768FW21J3L;
InChIKey : GKEYKDOLBLYGRB-LGMDPLHJSA-N;
CAS number : 1044040-56-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1044040-56-3
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : SHR-1020;
Origin ID : C97512;
UMLS CUI : C3273460;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
