NCIt definition : An Fc-domain optimized, humanized monoclonal antibody directed against cancer stem
cells (CSCs), with potential immunomodulating and antineoplastic activities. After
binding of enoblituzumab to an as of yet not elucidated target expressed on CSCs and
differentiated tumor cells, this agent may induce an antibody-dependent cell-mediated
cytotoxicity (ADCC) against CSCs. CSCs are tumor initiating cells that are able to
self-renew and are responsible for tumor cell growth and resistance.;
UNII : M6030H73N9;
CAS number : 1353485-38-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1353485-38-7
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G-SRS /a ;
Semantic type(s)