Preferred Label : Multi-subtype Natural Human Leukocyte Interferon Alpha;
NCIt synonyms : Multisubtype Natural Human Interferon Alpha;
NCIt definition : A preparation containing a mixture of multiple naturally occurring, active subtypes
1, 2, 8, 10, 14 and 21 of interferon alpha (IFN-alpha) with immunomodulating, anti-viral
and anti-cancer activities. Multi-subtype natural human leukocyte IFN-alpha is purified
from the leukocyte fraction of human blood challenged with Sendai virus. Upon administration,
IFN-alpha subtypes bind to cell surface IFN-alpha receptors (IFNARs), resulting in
an upregulation of interferon stimulated genes and related protein products. This
ultimately leads to the proliferation of human B cells, activation of natural killer
(NK) cells and dendritic cells (DCs), an increase in HLA-I and HLA-II expression and
activation of CD8-lymphocytes. Compared to single-subtype IFN, multi-subtypes act
synergistically.;
Drug name : Multiferon;
NCI Metathesaurus CUI : CL430253;
Origin ID : C97509;
UMLS CUI : C3273456;
Semantic type(s)
- concept_is_in_subset
