Naloxegol - CISMeF

Preferred Label : Naloxegol;

NCIt synonyms : Morphinan-3,14-diol, 4,5-Epoxy-6-(3,6,9,12,15,18,21-heptaoxadocos-1-yloxy)- 17-(2-propenyl)-, (5alpha,6alpha)-;

NCIt definition : A pegylated form of naloxone, a peripherally-acting mu-opioid receptor antagonist, that can be used to reduce opioid-induced symptoms. Upon administration, naloxegol binds to and blocks mu-opioid receptors in the peripheral nervous system. This prevents peripheral opioid receptor activation and abrogates opioid-induced side effects, such as opioid-induced constipation (OIC). Pegylation of naloxone reduces permeability across the blood-brain barrier (BBB) and prevents this agent from interfering with the analgesic activity of opioid receptor agonists.;

UNII : 44T7335BKE;

InChIKey : XNKCCCKFOQNXKV-ZRSCBOBOSA-N;

CAS number : 854601-70-0;

Drug name : Movantik;

Molecule name : NKTR-118; AZ13337019;

Details

Origin ID

C97506;

UMLS CUI

C3700399;

Currated CISMeF NLP mapping
- Naloxegol [ICD-11 Extension code]
- Naloxegol [SMS substance]
- Naloxegol (substance) [SNOMED CT concept]
- naloxegol [MeSH Supplementary Concept]
- naloxegol [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Naloxegol (substance) [SNOMED CT concept]
- Product containing naloxegol (medicinal product) [SNOMED CT concept]
- naloxegol [ATC Code]
- naloxegol [MeSH concept]
- naloxegol [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- naloxegol [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_salt_form
- Naloxegol Oxalate [NCIt concept]
is_free_acid_or_base_form_of
- Naloxegol Oxalate [NCIt concept]

Keyword's position in hierarchy(ies) :

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