NCIt synonyms : OPHN1L1; GRAF; KIAA0621; GTPase Regulator Associated With the Focal Adhesion Kinase pp125 Gene; OPHN1L; FLJ42530; Rho GTPase Activating Protein 26 wt Allele;
NCIt definition : Human ARHGAP26 wild-type allele is located in the vicinity of 5q31 and is approximately
459 kb in length. This allele, which encodes Rho GTPase-activating protein 26, is
involved in the modulation of signaling by both transforming protein RhoA and cell
division control protein 42 homolog. Both mutation of the gene and a chromosomal translocation
t(5;11)(q31;q23) of this gene and the MLL gene are associated with juvenile myelomonocytic
leukemia.;