Preferred Label : Acinterferon Alfa;
NCIt synonyms : Recombinant IFN Alfa-2b-like Protein; Recombinant Interferon Alpha 2b-like Protein;
NCIt definition : A proprietary recombinant protein highly resembling human interferon alpha 2b (IFN-a2b),
with potential anti-tumor, anti-inflammatory, immunomodulating and antiviral activities.
Upon injection, acinterferon alfa binds to specific IFN alpha cell surface receptors.
This activates interferon-mediated signal transduction pathways and induces the transcription
and translation of genes with interferon-specific response elements (ISREs). This
may activate the immune system, including the activation of natural killer cells (NKs)
and may result in an inhibition of tumor cell proliferation, tumor angiogenesis, metastasis
and an induction of apoptosis. Compared to human IFN-a2b (HuINF-a2b), this agent exhibits
enhanced antiviral and antiproliferative activities. In addition, this agent exhibits
antiviral activity against a variety of viruses, including hepatitis B and C viruses,
human immunodeficiency virus (HIV) and Avian Influenza.;
UNII : H9CK7SS0T6;
CAS number : 2941004-21-1;
Drug name : Novaferon;
Origin ID : C97503;
UMLS CUI : C3273450;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
