Preferred Label : Recombinant Interferon Alpha 2b-like Protein;
NCIt synonyms : Recombinant IFN Alfa-2b-like Protein;
NCIt related terms : NOVAFERON;
NCIt definition : A proprietary recombinant protein highly resembling human interferon alpha 2b (IFN-a2b),
with potential anti-tumor, anti-inflammatory, immunomodulating and antiviral activities.
Upon injection, recombinant IFN alpha 2b-like protein binds to specific IFN alpha
cell surface receptors. This activates interferon-mediated signal transduction pathways
and induces the transcription and translation of genes with interferon-specific response
elements (ISREs). This may activate the immune system, including the activation of
natural killer cells (NKs) and may result in an inhibition of tumor cell proliferation,
tumor angiogenesis, metastasis and an induction of apoptosis. Compared to human IFN-a2b
(HuINF-a2b), this agent exhibits enhanced antiviral and antiproliferative activities.
In addition, this agent exhibits antiviral activity against a variety of viruses,
including hepatitis B and C viruses, human immunodeficiency virus (HIV) and Avian
Influenza.;
UNII : H9CK7SS0T6;
Drug name : Novaferon;
Origin ID : C97503;
UMLS CUI : C3273450;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
