Cobicistat - CISMeF

Preferred Label : Cobicistat;

NCIt synonyms : 2,7,10,12-Tetraazatridecanoic Acid, 12-Methyl-13-(2-(1-methylethyl)-4-thiazolyl)-9-(2-(4-morpholinyl)ethyl)-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-Thiazolylmethyl Ester, (3R,6R,9S)-;

NCIt definition : A cytochrome P450 3A (CYP3A) inhibitor that can be used to enhance the pharmacokinetic profile of certain anti-HIV-1 agents. Upon administration, cobicistat inhibits the liver enzyme CYP3A4 and limits the breakdown of co-administered agents that are metabolized by CYP3A4, and increases the concentration, systemic exposure and efficacy of the co-administered agent.;

UNII : LW2E03M5PG;

InChIKey : ZCIGNRJZKPOIKD-CQXVEOKZSA-N;

CAS number : 1004316-88-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1004316-88-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Tybost;

Molecule name : GS 9350;

Chemical formula : C40H53N7O5S2;

Details

Origin ID

C97360;

UMLS CUI

C3177235;

Automatic exact mappings (from CISMeF team)
- Cobicistat [ICD-11 Extension code]
CISMeF manual mappings
- Cobicistat [MeSH Descriptor]
- Cobicistat (substance) [SNOMED CT concept]
Currated CISMeF NLP mapping
- Product containing cobicistat (medicinal product) [SNOMED CT concept]
- cobicistat [MeSH concept]
- cobicistat [International Nonproprietary Name]
- cobicistat [ATC Code]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Cobicistat [MeSH Descriptor]
- Cobicistat (substance) [SNOMED CT concept]
- Product containing cobicistat (medicinal product) [SNOMED CT concept]
- cobicistat [ATC Code]
- cobicistat [MeSH concept]
- cobicistat [International Nonproprietary Name]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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