NCIt definition : A proprietary adjuvant, applicable for water-in-oil (W/O; 30/70 v/v) vaccine emulsion,
with potential immunoadjuvant activity. Montanide ISA 720 is made of natural metabolizable
non-mineral oil and a highly refined emulsifier from the mannide mono-oleate family;
it is rapidly metabolized and eliminated, and may be used in various vaccines, including
cancer vaccines. Upon administration, Montanide ISA 720 forms a depot at the injection
site and is therefore capable of slowly releasing the antigen(s) from the injection
site. This may result in enhanced cellular and humoral immune responses to the antigen
vaccine.;