PBX1 wt Allele

Preferred Label : PBX1 wt Allele;

NCIt synonyms : Pre-B-Cell Leukemia Homeobox 1 wt Allele; MGC126627; PRL; DKFZp686B09108;

NCIt definition : Human PBX1 wild-type allele is located in the vicinity of 1q23 and is approximately 296 kb in length. This allele, which encodes pre-B-cell leukemia transcription factor 1 protein, is involved in transcriptional regulation. A chromosomal translocation t(1;19)(q23;p13.3) of this gene and the TCF3 gene is associated with pre-B-cell acute lymphoblastic leukemia. A second translocation of this gene and the EWSR1 gene may be associated with myoepithelioma.;

GenBank Accession Number : M86546;

Details

Origin ID

C97318;

UMLS CUI

C3273356;

OMIM relation
- Pre-b-cell leukemia transcription factor 1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 1q23 [NCIt concept]
gene_involved_in_pathogenesis_of_disease
- B Lymphoblastic Leukemia/Lymphoma with t(1;19)(q23;p13.3); TCF3-PBX1 [NCIt concept]
gene_is_element_in_pathway
- Glucocorticoid Receptor Regulatory Network [NCIt concept]
gene_plays_role_in_process
- Cell Differentiation Process [NCIt concept]
- DNA Binding [NCIt concept]
- Developmental Process [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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