ARHGEF7 wt Allele

Preferred Label : ARHGEF7 wt Allele;

NCIt synonyms : COOL-1; DKFZp686C12170; DKFZp761K1021; P85SPR; RP11-494P5.1; P50; SH3 Domain-Containing Proline-Rich Protein Gene; P85COOL1; Nbla10314; BETA-PIX; KIAA0412; Rho Guanine Nucleotide Exchange Factor (GEF) 7 wt Allele; PAK3; P50BP; PIXB; KIAA0142; PAK-Interacting Exchange Factor Beta Gene; P85; COOL1;

NCIt definition : Human ARHGEF7 wild-type allele is located in the vicinity of 13q34 and is approximately 221 kb in length. This allele, which encodes rho guanine nucleotide exchange factor 7 protein, is involved in the regulation of both GTPase-mediated signaling and apoptosis.;

NCIt note : The methylation status of the ARHGEF7 gene in breast cancer may be associated with a higher metastatic potential. (Sci. Transl. Med. 2011; 3. DOI: 10.1126/scitranslmed.3001875.);

GenBank Accession Number : D63476;

Details

Origin ID

C97200;

UMLS CUI

C3273276;

OMIM relation
- Rho guanine nucleotide exchange factor 7 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 13q34 [NCIt concept]
gene_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Aurora A Signaling Pathway [NCIt concept]
- Internalization Pathway for Epidermal Growth Factor Receptor [NCIt concept]
gene_plays_role_in_process
- Positive Regulation of Apoptosis [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients