Preferred Label : Topical Wound Spray HP802-247;
NCIt synonyms : Allogeneic Keratinocyte/Fibroblast Topical Spray HP802-247;
NCIt definition : A cell-based combination product consisting of a fibrinogen solution and a cell preparation
containing allogeneic non-proliferating, living human skin-derived keratinocytes and
fibroblasts, suspended in thrombin, with potential topical wound healing enhancing
and topical anti-ulcer activity. Upon sequential spray of the two components of HP802-247
topically, a thin fibrin matrix is formed on the wound surface and the cellular components
are capable of secreting wound healing cytokines and growth factors, such as vascular
endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), granulocyte-macrophage
colony-stimulating growth factor (GM-CSF) and keratinocyte growth factor. Cell concentration
and keratinocyte-to-fibroblast ratio in HP802-247 are essential for optimal growth
factor production and thus the efficacy of this agent.;
Molecule name : HP802-247;
NCI Metathesaurus CUI : CL429687;
Origin ID : C97133;
UMLS CUI : C3273249;
Semantic type(s)
- concept_is_in_subset
