Droloxifene - CISMeF

Preferred Label : Droloxifene;

NCIt synonyms : (E)-alpha[p-[2-(dimethylamino)ethoxy]phenyl]-alpha'-ethyl-3-stilbenol; (E)-3-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol; (E)--1-[4'-(2-dimethylaminoethyoxy)phenyl]-1(3-hydroxyphenyl)-2-phenyl-but-1-ene; 3-Hydroxytamoxifen;

NCIt definition : A phenolic analogue of tamoxifen, a nonsteroidal selective estrogen receptor modulator (SERM). Droloxifene competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. (NCI);

UNII : 0M67U6Z98F;

InChIKey : ZQZFYGIXNQKOAV-OCEACIFDSA-N;

CAS number : 82413-20-5;

Chemical formula : C26H29NO2;

Codes from synonyms : 20045;

Details

Origin ID

C969;

UMLS CUI

C0047498;

Currated CISMeF NLP mapping
- droloxifene [MeSH concept]
- droloxifene [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- droloxifene [MeSH concept]
- droloxifene [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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