EGFR-TKI Resistant Mutation

Preferred Label : EGFR-TKI Resistant Mutation;

NCIt synonyms : EGFR Mutation Resulting in Tyrosine Kinase Inhibitor Resistance; EGFR Tyrosine Kinase Inhibitor Resistant Mutation;

NCIt definition : A molecular genetic abnormality indicating the presence of resistance in the epidermal growth factor receptor-tyrosine kinase inhibitor domain, due to secondary mutations of the EGFR gene.;

Details

Origin ID

C96862;

UMLS CUI

C3273084;

Semantic type(s)
- Cell or Molecular Dysfunction [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_mutant_encodes_gene_product_sequence_variation
- EGFR NP_005219.2:p.T790M [NCIt concept]
- EGFR Protein Variant [NCIt concept]
molecular_abnormality_involves_gene
- EGFR Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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