Amsacrine Lactate

Preferred Label : Amsacrine Lactate;

NCIt synonyms : m-AMSA lactate; N-(4-(9-Acridinylamino)-3-methoxyphenyl)methanesulfonamide compd. with Lactic Acid; Methanesulfon-m-anisidide, 4'-(9-acridinylamino)-, compd. with Lactic Acid;

NCIt definition : The lactate form of amsacrine, an aminoacridine analog and topoisomerase II inhibitor, with antineoplastic activity. Although the exact relationship between DNA binding and its activity has yet to be fully elucidated, amsacrine intercalates DNA through its acridine moiety, and its nonintercalative headgroup impedes topoisomerase II activity, augmenting enzyme-mediated DNA cleavage and resulting in DNA double-strand breaks. This ultimately induces programmed cell death.;

UNII : 959PWE0Q2E;

InChIKey : NYGZSXVEKMITFN-UHFFFAOYSA-N;

CAS number : 80277-11-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 80277-11-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C21H19N3O3S.C3H6O3;

NSC code : 141549;

Details

Origin ID

C96771;

UMLS CUI

C1271552;

Automatic exact mappings (from CISMeF team)
- Amsacrine lactate (substance) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Amsacrine lactate (substance) [SNOMED CT concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Amsacrine [NCIt concept]
is_salt_form_of
- Amsacrine [NCIt concept]

Keyword's position in hierarchy(ies) :

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