Preferred Label : Anti-prolactin Receptor Antibody LFA102;
NCIt definition : A neutralizing antibody against the prolactin receptor (PRLR) with potential antineoplastic
activity. Upon administration, anti-prolactin receptor antibody LFA102 binds to PRLR
and prevents the binding of the peptide hormone prolactin (PRL) to its receptor. This
binding induces an antibody-dependent cellular cytotoxicity (ADCC) and may eventually
prevent tumor cell proliferation in PRLR-positive cancer cells. PRLR/PRL signaling
pathway is frequently overexpressed in breast and prostate cancer.;
Molecule name : LFA102;
NCI Metathesaurus CUI : CL429368;
Origin ID : C96744;
UMLS CUI : C3273002;
Semantic type(s)
- concept_is_in_subset
- has_target
