Preferred Label : Androgen Receptor Antisense Oligonucleotide EZN-4176;
NCIt definition : A locked nucleic acid (LNA)-based antisense oligonucleotide targeting the androgen
receptor (AR) mRNA, with potential antineoplastic activity. Upon administration, EZN-4176
is hybridized and releases the complementary sequences of AR mRNA, thereby blocking
translation of the AR protein and inhibiting AR-induced tumor cell growth and promoting
tumor cell apoptosis in AR-overexpressing tumor cells. AR is overexpressed in certain
breast and prostate cancers and is involved in tumor cell proliferation and survival.
LNAs contain a methylene bridge linking 2'-oxygen and 4'-carbon of ribose sugar rings,
thereby increasing their thermal stability and decreasing degradation.;
Molecule name : EZN-4176;
Origin ID : C96742;
UMLS CUI : C3273001;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
