Preferred Label : CR2-fH Fusion Protein TT30;
NCIt definition : A recombinant, chimeric human fusion protein consisting of the iC3b/C3d-binding region
of human complement receptor type 2 (CR2/CD21) linked to the alternative complement
pathway (ACP) inhibitory domain of human factor H (fH) (CR2-fH), with potential complement
system inhibiting activity. Via its C3 binding domain, TT30 selectively binds to complement
activated cell surfaces and via its fH binding domain regulates ACP activity. This
suppresses excessive complement activity and may result in an inhibition of ACP-mediated
hemolysis of paroxysmal nocturnal hemoglobinuria (PNH) red blood cells (RBCs) as well
as preventing ACP-induced tissue damage. Factor H is a key regulator in the activation
of ACP.;
Molecule name : TT30;
NCI Metathesaurus CUI : CL429365;
Origin ID : C96740;
UMLS CUI : C3272999;
Semantic type(s)
- concept_is_in_subset
- has_target
