Preferred Label : Ovarian Cancer Stem Cell/hTERT/Survivin mRNAs-loaded Autologous Dendritic Cell Vaccine
DC-006;
NCIt synonyms : DC-006 Vaccine;
NCIt definition : A cancer vaccine containing autologous dendritic cells (DCs) that are transfected
with mRNAs extracted from amplified ovarian cancer stem cells, and mRNAs of the universal
tumor antigens human telomerase reverse transcriptase (hTERT) and survivin with potential
immunostimulatory and antineoplastic activities. Upon administration, ovarian cancer
stem cell/hTERT/survivin mRNAs-loaded autologous DC-006 vaccine may elicit a highly
specific cytotoxic T-cell (CTL) response against ovarian cancer cells expressing hTERT,
survivin, and specific ovarian cancer stem cell antigens. hTERT, the catalytic subunit
of human telomerase, and survivin, a member of the inhibitor of apoptosis (IAP) family
of proteins, may be upregulated in certain tumor cell types, playing key roles in
tumor cell growth and survival. Ovarian cancer stem cells contain a specific range
of antigens that are essential for the neoplastic growth and survival of ovarian cancer
cells.;
Molecule name : DC-006;
NCI Metathesaurus CUI : CL429364;
Origin ID : C96739;
UMLS CUI : C4722472;
- Semantic type(s)
- concept_is_in_subset