Preferred Label : p.DOM-WT1-126 DNA Vaccine;
NCIt definition : A fusion DNA vaccine containing the first domain of fragment C (FrC) of tetanus toxin
(TT865-1120) (p.DOM) fused to the human Wilms' Tumor gene-1 (WT1)-derived MHC class
I-binding epitope WT1.126, with potential antitumor activity. Upon vaccination with
p.DOM-WT1-126 DNA and subsequent electroporation, this vaccine may induce a WT1 epitope-specific
cytotoxic T-lymphocyte (CTL) response against WT1 expressing cells, resulting in cell
lysis and inhibition of cancer cell proliferation in WT1-overexpressing cancer cells.
WT1, a tumor associated antigen, is overexpressed in most types of leukemia and in
a variety of solid cancers. The FrC of tetanus toxin contains the MHC II-binding sequence,
p30, which induces T-helper cell activation for long-lasting immunity.;
NCI Metathesaurus CUI : CL429363;
Origin ID : C96738;
UMLS CUI : C3272997;
Semantic type(s)
- concept_is_in_subset
