Recombinant B. pertussis Adenylate Cyclase Toxin-Tyrosinase A2 Epitope Vaccine

Preferred Label : Recombinant B. pertussis Adenylate Cyclase Toxin-Tyrosinase A2 Epitope Vaccine;

NCIt synonyms : Recombinant Bordetella pertussis Adenylate Cyclase Toxin-Tyrosinase.A2 Epitope YMDGTMSQV Vaccine;

NCIt definition : A recombinant vaccine containing a genetically detoxified adenylate cyclase toxin (CyaA) of Bordetella pertussis coupled, through its catalytic site, to the melanoma tyrosinase A2 epitope YMDGTMSQV, with potential antineoplastic activity. Via the toxin moiety, the recombinant B. pertussis adenylate cyclase toxin-tyrosinase A2 epitope specifically binds to the alphaMbeta2 integrin (CD11b/CD18) located on CD11b-positive antigen-presenting cells (APC). Upon processing and presentation of the melanoma-specific epitope by MHC class I molecules to the surface of these APCs, a specific cytotoxic T-cell (CTL) response against tumor cells expressing tyrosinase may be initiated, resulting in decreased tumor growth and cell lysis.;

NCI Metathesaurus CUI : CL429360;

Details

Origin ID

C96735;

UMLS CUI

C3272994;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

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