" /> Dichloromethotrexate - CISMeF





Preferred Label : Dichloromethotrexate;

NCIt synonyms : N-[3,5-Dichloro-4-[(2,4-diamino-6-pteridinylmethyl)methylamino]benzoyl] Glutamic Acid; 3'-5'-Dichloromethotrexate; L-Glutamic Acid, N-{3,5-dichloro-4-{[(2,4-diamino-6-pteridinyl)methyl]methylamino}benzoyl}-(9CI); Glutamic Acid, N-{3,5-dichloro-4-{[(2,4-diamino-6-pteridinyl)methyl]methylamino}benzoyl}-; DCM; Amethopterin, 3',5'-dichloro; Methotrexate, Dichloro; 3',5'-Dichloroamethopterin; Glutamic Acid, N-{3,5-dichloro-4-{[(2,4-diamino-6-pteridinyl)methyl]methylamino}benzoyl}-L- (8CI);

NCIt related terms : 3,5-Dichloromethotrexate; L-Glutamic acid, N-[3,5-dichloro-4-[[(2, 4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- (9CI); Dichloroamethopterin; Glutamic acid, N-[3,5-dichloro-4-[[(2, 4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L- (8CI); 3',5'-Dichloromethotrexate; Glutamic acid, N-[3,5-dichloro-4-[[(2, 4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-; Glutamic acid, N-(3,5-dichloro-4-([(2, 4-diamino-6-pteridinyl)methyl]methylamino)benzoyl)-; Amethopterin, 3',5'-dichloro-; Methotrexate, dichloro-; 3', 5'-Dichloroamethopterin; N-[3,5-Dichloro-4-[(2, 4-diamino-6-pteridinylmethyl)methylamino]benzoyl]glutamic acid;

NCIt definition : A chlorinated methotrexate derivative. Dichloromethotrexate inhibits the enzyme dihydrofolate reductase, thereby preventing the synthesis of purine nucleotides and thymidylates and inhibiting DNA and RNA synthesis. This agent is metabolized and excreted by the liver. (NCI04);

UNII : 29NS58S465;

CAS number : 528-74-5;

NSC code : 29630;

Codes from synonyms : NSC0029630;

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31/10/2025


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