Preferred Label : Dichloromethotrexate;
NCIt synonyms : N-[3,5-Dichloro-4-[(2,4-diamino-6-pteridinylmethyl)methylamino]benzoyl] Glutamic Acid; 3'-5'-Dichloromethotrexate; L-Glutamic Acid, N-{3,5-dichloro-4-{[(2,4-diamino-6-pteridinyl)methyl]methylamino}benzoyl}-(9CI); Glutamic Acid, N-{3,5-dichloro-4-{[(2,4-diamino-6-pteridinyl)methyl]methylamino}benzoyl}-; DCM; Amethopterin, 3',5'-dichloro; Methotrexate, Dichloro; 3',5'-Dichloroamethopterin; Glutamic Acid, N-{3,5-dichloro-4-{[(2,4-diamino-6-pteridinyl)methyl]methylamino}benzoyl}-L-
(8CI);
NCIt related terms : 3,5-Dichloromethotrexate; L-Glutamic acid, N-[3,5-dichloro-4-[[(2, 4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-
(9CI); Dichloroamethopterin; Glutamic acid, N-[3,5-dichloro-4-[[(2, 4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-,
L- (8CI); 3',5'-Dichloromethotrexate; Glutamic acid, N-[3,5-dichloro-4-[[(2, 4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-; Glutamic acid, N-(3,5-dichloro-4-([(2, 4-diamino-6-pteridinyl)methyl]methylamino)benzoyl)-; Amethopterin, 3',5'-dichloro-; Methotrexate, dichloro-; 3', 5'-Dichloroamethopterin; N-[3,5-Dichloro-4-[(2, 4-diamino-6-pteridinylmethyl)methylamino]benzoyl]glutamic acid;
NCIt definition : A chlorinated methotrexate derivative. Dichloromethotrexate inhibits the enzyme dihydrofolate
reductase, thereby preventing the synthesis of purine nucleotides and thymidylates
and inhibiting DNA and RNA synthesis. This agent is metabolized and excreted by the
liver. (NCI04);
UNII : 29NS58S465;
CAS number : 528-74-5;
NSC code : 29630;
Codes from synonyms : NSC0029630;
Origin ID : C966;
UMLS CUI : C0046764;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
