Napabucasin - CISMeF

Preferred Label : Napabucasin;

NCIt synonyms : 2-Acetylnaphtho(2,3-b)furan-4,9-dione;

NCIt definition : An orally available cancer cell stemness inhibitor with potential antineoplastic activity. Even though the exact target has yet to be fully elucidated, napabucasin appears to target and inhibit multiple pathways involved in cancer cell stemness. This may ultimately inhibit cancer stemness cell (CSC) growth as well as heterogeneous cancer cell growth. CSCs, self-replicating cells that are able to differentiate into heterogeneous cancer cells, appear to be responsible for the malignant growth, recurrence and resistance to conventional chemotherapies.;

UNII : Z1HHM49K7O;

InChIKey : DPHUWDIXHNQOSY-UHFFFAOYSA-N;

CAS number : 83280-65-3;

Molecule name : BBI-608; BB608;

NCI Metathesaurus CUI : CL429115;

Details

Origin ID

C96429;

UMLS CUI

C4287809;

Automatic exact mappings (from CISMeF team)
- napabucasin [MeSH Supplementary Concept]
- napabucasin [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- napabucasin [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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