ALOX12B wt Allele

Preferred Label : ALOX12B wt Allele;

NCIt synonyms : Arachidonate 12-Lipoxygenase, 12R Type wt Allele; 12R-LOX;

NCIt definition : Human ALOX12B wild-type allele is located in the vicinity of 17p13.1 and is approximately 15 kb in length. This allele, which encodes arachidonate 12-lipoxygenase, 12R-type protein, plays a role in arachidonic acid metabolism. Mutation of the gene is associated with non-bullous congenital ichthyosiform erythroderma.;

NCIt note : Mutations in the protein-coding region of the ALOX12B gene were found in multiple myeloma. (Nature. 2011; 471: 467-472.);

GenBank Accession Number : AF038461;

Details

Origin ID

C96338;

UMLS CUI

C3272720;

OMIM relation
- Arachidonate 12-lipoxygenase, r type [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 17p13.1 [NCIt concept]
gene_is_element_in_pathway
- Arachidonic Acid Metabolism Pathway [NCIt concept]
- IL23-Mediated Signaling Pathway [NCIt concept]
gene_plays_role_in_process
- Leukotriene Production [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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