Preferred Label : Fluorine F 18 Fluoro-PEG6-IPQA;
NCIt synonyms : 18F-fluoro-PEG6-IPQA; 4-[(3-iodophenyl)amino]-7-(2-[2-{2-(2-[2-{2-(18F-fluoroethoxy)-ethoxy}-ethoxy]-ethoxy)-ethoxy}-ethoxy]-quinazoline-6-yl-acrylamide); [(18)F]F-PEG6-IPQA;
NCIt definition : A radioconjugate containing the tracer PEG6-IPQA labeled with fluorine F 18 for potential
tumor imaging using positron emission tomography (PET). Upon administration, the IPQA
moiety of fluorine F 18 fluoro-PEG6-IPQA selectively targets and irreversibly binds
to the constitutively active mutant L858R of epidermal growth factor receptor (EGFR)
kinase, thereby allowing the visualization of tumor cells expressing the active mutant
L858R EGFR using PET. This can be used to select EGFR kinase inhibitors that bind
in a similar manner as this tracer and may allow individualized therapy for patients
that respond well to these types of EGFR kinase inhibitors. The presence of the L858R
EGFR mutation in non small cell lung cancer (NSCLC) cells is correlated with a better
response to EGFR kinase inhibitors compared to wild-type (WT) or L858R/T790M EGFR
dual-mutant.;
Origin ID : C96235;
UMLS CUI : C3180861;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
