NCIt definition : A replication-competent oncolytic parvovirus with potential antineoplastic activity.
Upon infection of host cells, parvovirus H-1 preferentially replicates in tumor cells
compared to healthy normal cells, thereby potentially resulting in tumor cell lysis
and leading to an inhibition of tumor cell proliferation. In addition, H1-infected
tumor cells strongly induce the release of the inducible heat shock protein 72 (Hsp72i),
which chaperone tumor associated antigens in the H1-mediated tumor lysates and may
activate antigen presenting cells (APCs), thereby leading to antitumor immune responses.
Parvovirus H-1 does not cause any pathogenic effect in normal, healthy cells and is
able to cross the blood brain barrier (BBB).;
Currated CISMeF NLP mapping