Preferred Label : Hydroxyprogesterone Caproate;
NCIt synonyms : 17alpha-Hydroxyprogesterone Caproate;
NCIt related terms : 17-[(1-Oxohexyl)oxy]pregn-4-ene-3,20-dione; Delalutin;
NCIt definition : A synthetic progestational agent similar to the endogenous progesterone used in hormone
therapy or as a female contraceptive. Mimicking the action of progesterone, hydroxyprogesterone
caporate binds to and activates nuclear progesterone receptors in the reproductive
system and causes the ligand-receptor complex to be translocated to the nucleus where
it binds to and promotes expression of target genes. Due to the negative feedback
mechanism seen with progesterone, this agent also blocks luteinizing hormone (LH)
release from the pituitary gland, thereby leading to an inhibition of ovulation and
an alteration in the cervical mucus and endometrium. Furthermore, without stimulation
of LH, estrogen release from the ovaries is stopped, hence impeding the growth of
estrogen-sensitive tumor cells.;
UNII : 276F2O42F5;
InChIKey : DOMWKUIIPQCAJU-LJHIYBGHSA-N;
CAS number : 630-56-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 630-56-8
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G-SRS /a ;
Drug name : Delalutin; Makena;
Chemical formula : C27H40O4;
NSC code : 17592;
Codes from synonyms : NSC0017592; 01767;
Origin ID : C960;
UMLS CUI : C0044971;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
