Preferred Label : Tezacitabine Anhydrous;
NCIt synonyms : 2'-Deoxy-2'-(fluoromethylene)cytidine Anhydrous; FMdC Anhydrous;
NCIt definition : The anhydrous form of tezacitabine, a synthetic pyrimidine nucleoside analogue with
potential antineoplastic activity. Phosphorylated by cellular kinases, tezacitabine
is converted into its active diphosphate and triphosphate metabolites. Tezacitabine
diphosphate binds to and irreversibly inhibits the activity of the enzyme ribonucleotide
reductase (RNR), which may result in the inhibition of DNA synthesis in tumor cells
and eventually tumor cell apoptosis. Tezacitabine triphosphate acts as a substrate
for DNA polymerase, thereby further inhibiting DNA replication. RNR catalyzes the
conversion of ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates,
a necessary step for DNA synthesis, and is overexpressed in many tumor cell types.;
UNII : 7607Y95N9S;
InChIKey : GFFXZLZWLOBBLO-ASKVSEFXSA-N;
CAS number : 130306-02-4;
Chemical formula : C10H12FN3O4;
Origin ID : C95916;
UMLS CUI : C3272436;
Semantic type(s)
- concept_is_in_subset
