Preferred Label : G-Quadruplex Stabilizer BMVC;
NCIt synonyms : 3,6-bis[2-(1-methylpyridinium)vinyl]carbazole Diiodide; 3,6-bis (1-methyl-4-vinylpyridinium) Carbazole Diiodide; BMVC;
NCIt definition : A carbazole derivative (3,6-bis[2-(1-methylpyridinium)vinyl]carbazole diiodide) that
selectively targets to the G-quadruplex DNA structure, used as a fluorescent probe
for cancer cytological diagnosis and with potential antitumor activity. G-quadruplex
stabilizer BMVC, preferentially uptaken by cancer cells, binds to and stabilize the
telomeric G-quadruplex structure at the end of DNA; when visualized with fluorescent
imaging device, BMVC emits bright fluorescent light and can be used to differentiate
tumor cells from normal cells. The BMVC/G-quadruplex complexes also interfere with
the activity of telomerase, which is highly active in tumor cells and plays a key
role in tumorigenesis while expressed at very low levels in most somatic cells.;
NCI Metathesaurus CUI : CL428290;
Origin ID : C95893;
UMLS CUI : C3272417;
Semantic type(s)
- concept_is_in_subset
