PI3K-delta Inhibitor AMG 319

Preferred Label : PI3K-delta Inhibitor AMG 319;

NCIt synonyms : PI3K Inhibitor ACP-319;

NCIt related terms : AMG-319;

NCIt definition : A highly selective, potent, and orally bioavailable small molecule inhibitor of the delta isoform of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K) with potential immunomodulating and antineoplastic activities. PI3K-delta inhibitor AMG 319 prevents the activation of the PI3K signaling pathway through inhibition of the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), thus decreasing proliferation and inducing cell death. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic lineages. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells.;

UNII : 19DG7G1U5Q;

InChIKey : KWRYMZHCQIOOEB-LBPRGKRZSA-N;

CAS number : 1608125-21-8;

Molecule name : AMG 319; ACP-319;

NCI Metathesaurus CUI : CL428288;

Details

Origin ID

C95891;

UMLS CUI

C4045825;

Currated CISMeF NLP mapping
- N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine [MeSH Supplementary Concept]
See also inter- (CISMeF)
- AMG319 [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform [NCIt concept]

Keyword's position in hierarchy(ies) :

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