" /> PI3K-delta Inhibitor AMG 319 - CISMeF





Preferred Label : PI3K-delta Inhibitor AMG 319;

NCIt synonyms : PI3K Inhibitor ACP-319;

NCIt related terms : AMG-319;

NCIt definition : A highly selective, potent, and orally bioavailable small molecule inhibitor of the delta isoform of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K) with potential immunomodulating and antineoplastic activities. PI3K-delta inhibitor AMG 319 prevents the activation of the PI3K signaling pathway through inhibition of the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), thus decreasing proliferation and inducing cell death. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic lineages. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells.;

UNII : 19DG7G1U5Q;

InChIKey : KWRYMZHCQIOOEB-LBPRGKRZSA-N;

CAS number : 1608125-21-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1608125-21-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : AMG 319; ACP-319;

NCI Metathesaurus CUI : CL428288;

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12/05/2024


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