Preferred Label : Preimplantation Factor PIF-1;
NCIt synonyms : PIF-1 Peptide;
NCIt related terms : PREIMPLANTATION FACTOR;
NCIt definition : A synthetic version, known as PIF-1, of the peptide Preimplantation Factor (PIF),
an embryo-secreted peptide, with potential activity against Graft-versus-Host Disease
(GVHD). PIF-1 is believed to have wide-ranging activity on the immunologic system,
including a whole host of immunologic changes that resemble pregnancy, in which there
is neither graft-versus-host or host-versus-graft disease between the mother and the
embryo. Replication of the immunologic profile of pregnancy through the administration
of PIF-1 may thus benefit patients undergoing bone marrow transplant (BMT) who experience
graft-versus-host disease (GVHD). Native embryonic PIF has been found to have a multi-targeted
effect on various aspects of the immune system, coordinated so that there is a successful
embryonic implantation and a successful pregnancy.;
UNII : 3K6A6FJ98O;
CAS number : 485818-40-4;
Molecule name : PIF-1;
NCI Metathesaurus CUI : CL428287;
Origin ID : C95890;
UMLS CUI : C3272414;
Semantic type(s)
- concept_is_in_subset
