" /> Carbon C 11 Alpha-methyltryptophan - CISMeF





Preferred Label : Carbon C 11 Alpha-methyltryptophan;

NCIt synonyms : alpha-[11C]methyl-L-tryptophan; 11C-alpha-methyltryptophan; [11C] AMT; 11C-AMT;

CISMeF synonym : alpha-[11C]-methyl-l-tryptophan;

NCIt related terms : .ALPHA.-METHYL-L-TRYPTOPHAN C-11;

NCIt definition : A radiopharmaceutical containing an analogue of tryptophan, alpha-methyltryptophan (AMT), labeled with carbon 11 (11C), used to measure serotonin synthesis in the human brain using positron emission tomography (PET). Upon administration and once it crosses the blood-brain barrier and into the cytoplasm of serotonergic neurons, carbon C 11 alpha-methyltryptophan acts as a substrate for the enzyme tryptophan hydroxylase and undergoes conversion to carbon C 11 alpha-methyl-5-hydroxytryptophan, also known as C 11 alpha-methyl-serotonin (AMS). C 11 AMS accumulates in serotonergic nerve terminals in proportion to the synthesis rate of serotonin because C 11 AMS cannot be broken down by the enzyme monoamine oxidase, and thus the synthesis rate of serotonin can be imaged using PET. C 11 AMT is not incorporated into proteins, nor are metabolites released into the blood pool, making C 11 AMT an excellent tracer for serotonin synthesis in vivo.;

UNII : 0T6U1DP1TQ;

CAS number : 157399-98-9;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
06/05/2025


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.