Preferred Label : Amuvatinib Hydrochloride;
NCIt synonyms : MP-470 HCI; N-(1,3-Benzodioxol-5-Ylmethyl)-4-(Benzofuro(3,2-D)Pyrimidin-4-Yl)Piperazine-1- Carbothioamide
Monohydrochloride; 1-Piperazinecarbothioamide, N-(1,3-Benzodioxol-5-Ylmethyl)-4-Benzofuro(3,2-D)Pyrimidin-4-Yl-,
Hydrochloride (1:1);
NCIt definition : The hydrochloride salt of an orally bioavailable synthetic carbothioamide with potential
antineoplastic activity. Multitargeted receptor tyrosine kinase inhibitor MP470 binds
to mutant forms of the stem cell factor receptor (c-Kit; SCFR), inhibiting clinically
relevant mutants of this receptor tyrosine kinase that may be associated with resistance
to therapy. In addition, MP470 inhibits activities of other receptor tyrosine kinases,
such as c-Met, Ret oncoprotein, and mutant forms of Flt3 and PDGFR alpha, which are
frequently dysregulated in variety of tumors. This agent also suppresses the induction
of DNA repair protein Rad51, thereby potentiating the activities of DNA damage-inducing
agents. Mutant forms of c-Kit are often associated with tumor chemoresistance.;
UNII : 14L8O2K12B;
InChIKey : IKQFRXPMBGQJGE-UHFFFAOYSA-N;
CAS number : 1055986-67-8;
Molecule name : HPK56 HCl; MP470 HCl;
Chemical formula : C23H21N5O3S.HCl;
Origin ID : C95776;
UMLS CUI : C2987416;
Semantic type(s)
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
