Preferred Label : Crystalline Genistein Formulation AXP107-11;
NCIt synonyms : Crystalline Genistein Sodium Dihydrate;
NCIt definition : The sodium salt dihydrate form of crystalline genistein, a soy-derived isoflavone
and phytoestrogen, with potential antineoplastic, chemosensitizing, and antioxidant
activities. Upon administration, crystalline genistein formulation AXP107-11 binds
to and modulates the activities of the nuclear estrogen receptors ERalpha (ESR1) and
ERbeta (ESR2), and activates the G-coupled estrogen receptor 1 (GPER1). In addition,
this agent increases the expression of phosphatase and tensin homolog (PTEN), which
deactivates protein kinase Akt and mitogen-activated protein kinases (MAPK1 and 3;
ERK2 and 1), thereby disrupting PI3K/Akt signal transduction and inducing apoptosis.
AXP107-11 also induces antioxidant enzymes through AMP-activated protein kinase (AMPK)
activation, inhibits nuclear factor kappa-B (NF-kB) activation and decreases inflammation
response, thereby sensitizing tumors to chemotherapy. Compared to genistein itself,
which has poor oral availability, this crystalline formulation shows improved solubility
and bioavailability.;
Molecule name : AXP107-11;
NCI Metathesaurus CUI : CL428211;
Origin ID : C95769;
UMLS CUI : C2987410;
Semantic type(s)
- concept_is_in_subset
