Preferred Label : Genistein Sodium Dihydrate;
NCIt synonyms : Crystalline Genistein Sodium Dihydrate; Crystalline Genistein Formulation AXP107-11;
NCIt definition : The sodium salt dihydrate form of crystalline genistein, a soy-derived isoflavone
and phytoestrogen, with potential antineoplastic, chemosensitizing, and antioxidant
activities. Upon administration, genistein sodium dihydrate binds to and modulates
the activities of the nuclear estrogen receptors ERalpha (ESR1) and ERbeta (ESR2),
and activates the G-coupled estrogen receptor 1 (GPER1). In addition, this agent increases
the expression of phosphatase and tensin homolog (PTEN), which deactivates protein
kinase Akt and mitogen-activated protein kinases (MAPK1 and 3; ERK2 and 1), thereby
disrupting PI3K/Akt signal transduction and inducing apoptosis. Genistein sodium dihydrate
also induces antioxidant enzymes through AMP-activated protein kinase (AMPK) activation,
inhibits nuclear factor kappa-B (NF-kB) activation and decreases inflammation response,
thereby sensitizing tumors to chemotherapy. Compared to genistein itself, which has
poor oral availability, this crystalline formulation shows improved solubility and
bioavailability.;
UNII : Z6D785B7J3;
CAS number : 1229264-80-5;
Molecule name : AXP107-11;
NCI Metathesaurus CUI : CL428211;
Origin ID : C95769;
UMLS CUI : C2987410;
Semantic type(s)
- concept_is_in_subset
