Preferred Label : Egaptivon Pegol;
NCIt definition : An optimized, second-generation, PEGylated aptamer with antithrombotic property. Egaptivon
pegol blocks the binding of von Willebrand factor (vWF), via the A1 domain, and ultra-large
vWF multimers to platelets, as well as interferes with the binding of platelet receptor
glycoprotein Ib, thus reducing platelet adhesion, aggregation and thrombus growth
in arterial beds. Unlike other antiplatelet agents, this aptamer can be readily reversed
by binding to a complementary sequence of oligonucleotides, and may therefore offer
potential therapeutic benefit in surgery.;
UNII : DT0445S65M;
CAS number : 934868-74-3;
Molecule name : ARC1779; ARC 1779;
PubMed : 19479665;
Origin ID : C95742;
UMLS CUI : C4490515;
Semantic type(s)
- concept_is_in_subset
- has_target
