Preferred Label : Anti-CEA BiTE Monoclonal Antibody AMG211;
NCIt definition : A recombinant, proprietary bispecific T-cell engagers (BiTE) antibody directed against
human carcinoembryonic antigen (CEA), with potential immunostimulating and antineoplastic
activities. Anti-CEA BiTE monoclonal antibody AMG211 possesses two antigen-recognition
sites, one for CEA and one for the CD3 complex, a group of T cell surface glycoproteins
that complex with the T cell receptor (TCR). This bispecific monoclonal antibody brings
CEA-expressing tumor cells and cytotoxic T lymphocytes (CTLs) and helper T lymphocytes
(HTLs) together, which may result in the CTL- and HTL-mediated cell death of CEA-expressing
cells. CEA, a tumor associated antigen, is overexpressed in many cancer types, including
gastrointestinal, breast, non-small cell lung, and thyroid cancers.;
Molecule name : MT111; MEDI-565; AMG211;
NCI Metathesaurus CUI : CL428189;
PubMed : 19953093; 19342971;
Origin ID : C95728;
UMLS CUI : C3896918;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
