Preferred Label : pUMVC3-hIGFBP-2 Multi-epitope Plasmid DNA Vaccine;
NCIt definition : A recombinant plasmid DNA vaccine containing mammalian expression vector, pUMVC3,
encoding epitopes of human Insulin-Like Growth Factor-Binding Protein 2 (hIGFBP-2)
with potential antineoplastic activity. Upon vaccination, pUMVC3-hIGFBP-2 multi-epitope
plasmid DNA vaccine may produce IGFBP-2 that binds to cell surface, likely via integrin
complexes. This results in the dephosphorylation of the focal adhesion-kinase (FAK)
and of the p42/44 MAP-kinases, thereby inactivating them; both kinases are involved
in cell growth regulation. Furthermore, IGFBP-2 promotes de-adhesion of the cells
in a dose-dependent manner, hence impeding cell proliferation. The primary effect
of IGFBPs appears to be modulation of IGF activity and control of IGF-mediated cell
growth and metabolism.;
NCI Metathesaurus CUI : CL428188;
Origin ID : C95727;
UMLS CUI : C2987377;
Semantic type(s)
- concept_is_in_subset
- has_target
