Preferred Label : MTF-1 Inhibitor APTO-253 HCl;
NCIt synonyms : 2-(6-Fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenanthroline Hydrochloride;
NCIt related terms : APTO-253 HYDROCHLORIDE;
NCIt definition : The hydrochloride salt of a small molecule inhibitor of human metal-regulatory transcription
factor 1 (MTF-1) with potential antitumor activity. MTF-1 inhibitor APTO-253 inhibits
MTF-1 activity and thereby induces the expression of MTF-1 dependent tumor suppressor
factor Kruppel like factor 4 (KLF4). This subsequently leads to the downregulation
of cyclin D1, blocking cell cycle progression and proliferation. This agent also causes
decreased expression of genes involved in tumor hypoxia and angiogenesis.;
UNII : 266N56YWTZ;
CAS number : 1422731-37-0;
Molecule name : LOR-253 HCl; LT-253 HCl; APTO-253 HCl;
NCI Metathesaurus CUI : CL428185;
Origin ID : C95724;
UMLS CUI : C3896916;
Semantic type(s)
- concept_is_in_subset
