NCIt definition : A monoclonal antibody directed against the Notch receptor with potential antineoplastic
activity. Tarextumab binds to Notch on the cell surface, thereby inhibiting Notch-mediated
signaling and gene transcription, which may impede tumor angiogenesis. Notch receptors
are important for cell-cell communication, which involves gene regulation mechanisms
that control multiple cell differentiation processes during embryonic and adult life.
Dysregulated Notch signaling is implicated in many diseases including T-ALL (T-cell
acute lymphoblastic leukemia), CADASIL (Cerebral Autosomal Dominant Arteriopathy with
Sub-cortical Infarcts and Leukoencephalopathy), MS (Multiple Sclerosis), and many
other disease states.;