Liposomal c-raf Antisense Oligonucleotide

Preferred Label : Liposomal c-raf Antisense Oligonucleotide;

NCIt synonyms : c-raf Antisense Oligodeoxynucleotide Liposome; liposome-encapsulated c-raf Antisense Oligodeoxynucleotide; LErafAON;

NCIt definition : The liposomal formulation of a c-raf-1 antisense oligonucleotide, with potential antineoplastic activity. Liposomal c-raf antisense oligonucleotide targets the translation initiation site of human c-raf-1 mRNA, thereby blocking the expression and production of Raf-1 protein and thus inhibit tumor cell growth and development. Raf-1 plays a key role in the RAF/MEK/ERK signaling pathway, which regulates mammalian cell proliferation and growth. The liposomal formulation increases the solubility of the c-raf antisense oligonucleotide, thus improving its pharmacodynamic profile.;

Details

Origin ID

C95718;

UMLS CUI

C1436330;

Currated CISMeF NLP mapping
- LErafAON [MeSH concept]
- LErafAON [MeSH Supplementary Concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- LErafAON [MeSH concept]
- LErafAON [MeSH Supplementary Concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients