Preferred Label : Liposomal SN-38;
NCIt synonyms : SN-38 Liposome; LE-SN38; 7-Ethyl-10-hydroxycamptothecin Liposome;
NCIt definition : The liposomal formulation of SN-38 (7-ethyl-10-hydroxy-camptothecin), a biologically
active metabolite of the prodrug irinotecan, with potential antineoplastic activity.
SN-38 binds to and inhibits topoisomerase I by stabilizing the cleavable complex between
topoisomerase I and DNA, resulting in DNA breaks, inhibition of DNA replication, and
apoptosis. SN-38 has been reported to exhibit up to 1,000-fold more cytotoxic activity
against various cancer cells in vitro than irinotecan. The liposomal formulation of
SN-38 increases the solubility of SN-38, which is a relatively insoluble compound,
and improves the pharmacodynamic profile as compared to SN-38 alone.;
Origin ID : C95717;
UMLS CUI : C1328201;
Semantic type(s)
- concept_is_in_subset
