Preferred Label : CYL-02 Plasmid DNA;
NCIt definition : A gene transfer preparation of a plasmid DNA encoding mouse somatostatin receptor
subtype 2 (sst2) and a fusion protein of human deoxycytidine kinase (DCK) and uridine
monophosphate kinase (UMK), complexed to a synthetic polycationic carrier, polyethylenimine,
with antineoplastic adjuvant application. Upon administration, CYL-02 plasmid DNA
expresses DCK::UMK fusion protein that converts gemcitabine into its toxic phosphorylated
metabolite. Expression of sst2 protein by this agent could induce both antioncogenic
and local antitumor bystander effects. A loss of sst2 gene expression often is found
in pancreatic and colorectal cancers, and is the receptor for somatostatin which negatively
regulates a number of processes such as epithelial cell proliferation. Combination
effects of these gene products allows for less chemotherapy to cause tumor cell lysis
in not only the original tumor, but in distant tumors as well.;
Molecule name : CYL-02;
NCI Metathesaurus CUI : CL428180;
Origin ID : C95716;
UMLS CUI : C2987369;
Semantic type(s)
- concept_is_in_subset
