Labetuzumab Govitecan

Preferred Label : Labetuzumab Govitecan;

NCIt synonyms : Antibody-Drug Conjugate IMMU-130; ADC IMMU-130; hMN14-SN38;

NCIt related terms : Labetuzumab-SN-38 Immunoconjugate IMMU-130;

NCIt definition : An antibody-drug conjugate (ADC) containing labetuzumab, a mildly reduced, anti-CEACAM5 humanized monoclonal antibody, conjugated to the potent topoisomerase I inhibitor SN-38, with antineoplastic activity. The monoclonal antibody moiety of labetuzumab govitecan selectively binds to carcinoembryonic cell adhesion molecule 5 (CEACAM5), which is abundantly expressed on the surface of a majority of solid tumors. Upon internalization and proteolytic cleavage, SN-38, the active metabolite of irinotecan, inhibits the activity of topoisomerase I in the tumor cells, eventually inhibiting both DNA replication and transcription and leading to tumor cell apoptosis.;

UNII : 8E3HI6QQ9J;

CAS number : 1469876-18-3;

NCI Metathesaurus CUI : CL428175;

Details

Origin ID

C95710;

UMLS CUI

C4519108;

Currated CISMeF NLP mapping
- labetuzumab govitecan [MeSH Supplementary Concept]
- labetuzumab govitecan [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- labetuzumab govitecan [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 [NCIt concept]

Keyword's position in hierarchy(ies) :

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