Preferred Label : Palifosfamide Tromethamine;
NCIt synonyms : Palifosfamide Tris; Phosphorodiamidic Acid, N,N'-bis(2-chloroethyl)-, Compd. with 2-Amino-2-(hydroxymethyl)-1,3-propanediol
(1:1);
NCIt definition : A synthetic mustard compound of the tromethamine (tris) salt of palifosfamide (Isophosphamide
mustard), with potential antineoplastic activity. As the stabilized active metabolite
of ifosfamide, palifosfamide irreversibly alkylates and crosslinks DNA through GC
base pairs, resulting in irreparable 7-atom interstrand crosslinks. This leads to
an inhibition of DNA replication and ultimately cell death. Unlike ifosfamide, this
agent is not metabolized to acrolein or chloroacetaldehyde, metabolites associated
with bladder and CNS toxicities. In addition, because palifosfamide does not require
activation by aldehyde dehydrogenase, it may overcome the tumor resistance seen with
ifosfamide. Stabilization with tris instead of lysine further increases stability
and may further decrease nephrotoxicity.;
UNII : 0X5A3C04ID;
InChIKey : PGLRCMRTUIMSFQ-UHFFFAOYSA-N;
CAS number : 1070409-31-2;
Molecule name : ZIO-201-T;
Origin ID : C95703;
UMLS CUI : C2987344;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
