Preferred Label : Edelfosine;
NCIt synonyms : Edelfosinum; 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphocholine; ET-18-OCH3;
NCIt related terms : 1-Octadecyl-2-methoxy-rac-glycero-3-phosphocholine;
NCIt definition : A synthetic analog of lysophosphatidylcholine, an ether lipid, possessing anti-leishmanial
and antineoplastic activity. The mechanism of action for edelfosine has not been fully
elucidated. Targeting cellular membranes, edelfosine modulates membrane permeability,
membrane lipid composition, and phospholipid metabolism. Edelfosine also inhibits
the phosphatidylinositol 3 kinase (PI3K)-AKT/PKB survival pathway, possibly activating
the pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing
apoptosis. In addition, this agent inhibits protein kinase C, intracellular activation
of the Fas/CD95 receptor, and intracellular acidification. Anti-leishmanial activity
may be due to inhibition of a glycosomal alkyl-specific-acylCoA acyltransferase. (NCI);
UNII : 1Y6SNA8L5S;
InChIKey : MHFRGQHAERHWKZ-UHFFFAOYSA-N;
CAS number : 70641-51-9;
Chemical formula : C27H58NO6P;
NSC code : 324368;
Codes from synonyms : 30533; NSC0324368;
Origin ID : C956;
UMLS CUI : C0044549;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
