PDE5A wt Allele

Preferred Label : PDE5A wt Allele;

NCIt synonyms : PDE5; Phosphodiesterase Isozyme 5 Gene; CGB-PDE; Phosphodiesterase 5A, cGMP-Specific wt Allele; CN5A;

NCIt definition : Human PDE5A wild-type allele is located in the vicinity of 4q27 and is approximately 135 kb in length. This allele, which encodes cGMP-specific 3',5'-cyclic phosphodiesterase protein, is involved in the regulation of second messenger metabolism.;

NCIt note : Downregulation of the PDE5A gene by BRAF may be associated with malignant melanoma. (Cancer Cell. 2011; 19: 45-57.);

GenBank Accession Number : D89094;

Details

Origin ID

C95468;

UMLS CUI

C2987167;

OMIM relation
- Phosphodiesterase 5a [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_is_element_in_pathway
- Purine Metabolism Pathway [NCIt concept]
gene_plays_role_in_process
- Hydrolysis [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients