NCIt synonyms : Venombin-A; Acc-C; Brevinase; Arwin; Agkistrododon Rhodostoma Venom Proteinase; Proteinase, Agkistrodon Serine; Agkistrododon Protein C Activator; Arvin;
NCIt definition : A proteolytic enzyme and defibrinogenating agent derived from the venom of the Malayan
pit viper, with profibrinolytic and anticoagulant activities. Upon administration,
ancrod cleaves fibrinogen and releases A-fibrinopeptides. This inactivates fibrinogen
and leads to a reduction in blood viscosity, increases blood flow and perfusion of
the microcirculation.;