Preferred Label : Fostamatinib Disodium Anhydrous;
NCIt synonyms : R-788 Sodium Anhydrous; R-935788 Sodium Anhydrous; 2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one, 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-
4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-, Disodium Salt;
NCIt definition : The anhydrous form of fostamatinib disodium, an orally available Syk kinase inhibitor
with potential anti-inflammatory and immunomodulating activities. Fostamatinib inhibits
Syk kinase-mediated IgG Fc gamma receptor signaling, resulting in inhibition of the
activation of mast cells, macrophages, and B-cells and related inflammatory responses
and tissue damage. Syk kinase, widely expressed in hematopoietic cells, is a nonreceptor
tyrosine kinase that is involved in coupling activated immunoreceptors to signal downstream
events that mediate diverse cellular responses, including proliferation, differentiation,
and phagocytosis.;
UNII : X9417132K8;
InChIKey : HSYBQXDGYCYSGA-UHFFFAOYSA-L;
CAS number : 1025687-58-4;
Chemical formula : C23H24FN6O9P.2Na;
Origin ID : C95228;
UMLS CUI : C2987010;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
