Preferred Label : Allogeneic Renal Cell Carcinoma Vaccine MGN1601;
NCIt synonyms : IL-7/GM-CSF/CD80/CD154-encoding Synthetic dSLIM-30L1 Allogeneic Renal Cell Carcinoma
Vaccine MGN1601;
NCIt definition : A whole cell vaccine comprised of irradiated allogeneic renal cell carcinoma (RCC)
with potential immunostimulating and antineoplastic activities. Allogeneic renal cell
carcinoma vaccine MGN1601 contains two active ingredients: 1) genetically modified
allogeneic RCC cells that are transiently transfected with four different MIDGE (Minimalistic
Immunogenically Defined Gene Expression) vectors encoding IL-7, GM-CSF, CD80 and CD154
and 2) the synthetic DNA-based immunomodulator dSLIM-30L1, a TLR9 agonist.. Vaccination
results in expression of IL-7, GM-CSF, CD80 and CD154, which all contribute to the
activation or enhancement of immune responses. Furthermore, administration of this
RCC vaccine may elicit a cytotoxic T lymphocyte (CTL) response against similar host
tumor cells, resulting in decreased tumor growth. TLR9 is a member of the TLR family,
which plays a fundamental role in pathogen recognition and activation of innate immunity.;
Molecule name : MGN1601;
NCI Metathesaurus CUI : CL426701;
Origin ID : C95213;
UMLS CUI : C2986999;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
