Preferred Label : HLA-A*2402-Restricted VEGFR1/2 Multipeptide Vaccine;
NCIt definition : A cancer vaccine containing two HLA-A*2402-restricted peptide epitopes with potential
immunostimulatory and antitumor activities. Peptide epitopes in this vaccine are derived
from vascular endothelial growth factor receptors (VEGFRs) 1 and 2. Upon administration,
this peptide vaccine may stimulate a cytotoxic T lymphocyte (CTL) response against
VEGFR1- and VEGFR2-expressing tumor cells, resulting in tumor cell lysis and decreased
tumor growth. HLA-A*2402 is an MHC class I molecule that presents antigenic peptides
to CD8 T cells; epitope design restricted to epitopes that bind most efficiently
to HLA-A*2402 may improve antigenic peptide immunogenicity.;
NCI Metathesaurus CUI : CL426699;
Origin ID : C95211;
UMLS CUI : C2986997;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
